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Theme II: Prion Biology
Introduction
1. Identification of MiRNA Driven Regulatory Circuits Involved in Prion-Induced Neurodegeneration
2. Evolutionary Analysis and Structural Modelling of Prion Proteins and Prion Protein-like Molecules
3. Pathobiology of Prion Protein Aggregates: Mechanism of Toxicity and Propagation of Aggregates Produced in the Cytoplasm
4. Prion Protein Conversion in Disease: the “Demiglobule” Hypothesis
5. Molecular Mechanism for Oligomer Formation of Prion Proteins
6. NMR Studies of Protein Interactions, Conversion Intermediates and Oligomers of PrP
7. Protein Kinases as Potential Therapeutic Targets in Prion Diseases
8. Regulation of NMDA Receptors by Prion Proteins
9. PrPSC Specific Antibodies: Generation, Structural Analysis, Use as Tools and Diagnostic Assay Development
10. Discovery and Characterization of Novel Interactions Involving PrP and Related Proteins
11. Role of the Cellular Prion Protein in Regulating T Cell-Mediated Autoimmune Neuroinflammation
12. Oligomeric PrPres and Amyloidogenic PrP Fragments: their molecular structure, toxicity, and role in prion disease pathogenesis
13. PrP, ALS, and Autism Spectrum Disorders
14. Protein Folding Diseases in Zebrafish
15. Physiological Functions of the Cellular Prion Protein
16. Testing potential chemical chaperones for prions with single-molecule spectroscopies
17. Linking Prion Fibril Stability and Prion Infectivity
18. A Stress‐Regulated Cryptic Out‐of‐Frame Polypeptide encoded in the Prion
19. Exploitation of PrP Misfolding Epitopes in TSE Vaccines and Cancer Immunotherapies
20. The New ZIP on the Block: Structural Analyses of the ZIP-PrP Complex
21. Novel Inhibitor Development for Prion Conversion
22. Structural Characterization of the Fab fragments of three PrPc-specific Antibodies
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