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14. Protein Folding Diseases in Zebrafish

Principal Investigator: Ted Allison, University of Alberta

Co-Investigators:
David Westaway, University of Alberta

Project Description:
The goal of this project is the creation of transgenic and mutant zebrafish (DrosophilaI) that will represent a potent animal model of prion diseases and amyloidosis. The emerging power of zebrafish is rooted in the ability to efficiently alter gene function by routine transgenesis. Despite its quick development, including reaching sexual maturity by ~2.5 months, the zebrafish can live for 3-5 years, allowing time for the slow development of neuropathologies. The project  combines genetic and developmental tractability of culture of zebrafish with the study of in vivo brain development, degeneration, and repair in an intact vertebrate neural architecture.

(Recruitment)

Last Updated: 4/16/2010 6:36:14 PM