The Natural Psychedelic and the Clinical Product Hallucinogen

LSD and magic mushrooms are hallucinogens; one is a product of human experiment, the other is offered by nature. What is the difference between these hallucinogens?


Lysergic Acid Diethylamide (LSD) and PsilocybeCubensis (magic mushroom) fall under the same drug classification. Both are considered hallucinogens. Therefore, these substances have a chemical composition that interacts with the brain and induces euphoria. Moreover, both LSD and shrooms are strictly utilized for legalized medicinal purposes. The authorities still have not decriminalized the use of these substances for recreational purposes.

What is LSD? 

LSD was invented in 1938 by a Swiss chemist named Albert Hoffman. He synthesized the substance from ergot, a type of mold that grows on rye bread and grains.

LSD is a clear, odorless, and tasteless drug. It mimics the characteristics of ergot to which it came from, which is the reason why LSD has similar properties to psilocybin. Both are derived from a type of fungus.

This drug is consumed as a pill, liquid, or absorbed through a piece of paper soaked with LSD. It takes about an hour for LSD to take effect. It is also easy to ingest compared to magic mushrooms. It has no digestive effect even if a person consumes more LSD.

A person may develop tolerance to the drug when consumed over time. However, the same is true for any substance taken without regulation. It is why medical experts always remind people to take the drug in moderation. Since it is easy to ingest LSD, many forget to consume the substance in moderation resulting in longer duration and ‘bad’ trips. It explains why there are more reports of ‘bad’ LSD trips compared to shrooms.

If magic mushrooms affect the whole body, LSD, on the other hand, only affects the cerebral. It may also cause palpitation, increased blood pressure, tremors, numbness, and paranoia.

What is Magic Mushroom? 

Magic mushroom, also known as shroom, primarily grows on moist habitats and grasslands. Shrooms are under the species PsilocybeCubensis, it is a type of mushroom that contains psilocybin that is a hallucinogen.

Shrooms have a wide variety of species. Each one is unique in terms of potency, duration of effect, and potential medicinal properties. It is the reason why seasoned psychonauts suggest neophytes consult knowledgeable individuals about shrooms and reliable sources. For example, you can get a detailed explanation about shrooms from 3 amigos.

Psilocybin in shrooms activates brain receptors resulting in distorted senses and hallucinations. The effect of psilocybin kicks in after an hour from its consumption and may last depending on the dosage. Upon metabolism, psilocybin causes improvement in energy, mood, and brain activities. However, taking a high dosage of the substance could lead to nightmares, paranoia, and a distorted perception of reality.

Is it Safe to Mix LSD and Shroom? 

Both substances are hallucinogens; therefore, taking one hallucinogen with another will double the drug’s potency and effect.

Moreover, combining both hallucinogens increases the risk of serotonin syndrome. The brain recognizes LSD and shrooms as serotonin. Thus, consuming these substances at the same time will significantly increase the serotonin levels in the body resulting in serotonin syndrome. This condition may cause diarrhea, headache, loss of muscle coordination, muscle rigidity, fever, seizures, irregular heartbeat, and unconsciousness.

Severe serotonin syndrome is fatal. Hence, make sure to avoid taking two hallucinogens at once.